2020/06 - Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis [Journal Club]-Recording

Video Transcription

Video Summary

This JCMR Journal Club featured a discussion of a systematic review and meta-analysis on native T2 and T2* CMR values in cardiomyopathies and heart transplantation. Dr. Snell presented findings from 154 studies published between 2011 and 2019, focusing on how T2 and T2* values vary across diseases, field strengths, vendors, and acquisition methods.<br /><br />The analysis showed that T2* values were generally lower in patient groups than in controls, especially in myocardial infarction and iron overload, while T2 values were generally higher in patient groups, particularly in myocarditis, myocardial infarction, and heart transplant recipients. However, substantial heterogeneity was found across studies, driven by differences in scanner vendor, field strength, pulse sequence, region of interest selection, control selection, and patient demographics.<br /><br />A major takeaway was that reference values should be locally established and matched to the patient population, ideally using the same acquisition and analysis methods. The discussion emphasized that T2 may be most useful in diffuse inflammatory disease and acute myocarditis, while T2* remains especially important for iron overload and may have limited utility outside that setting. Standardization of acquisition and analysis was highlighted as essential for broader clinical adoption.

Keywords

systematic review

meta-analysis

native T2

T2* CMR

cardiomyopathy

heart transplantation

myocarditis

iron overload

standardization