2021/8 - Multi-parametric assessment of left ventricular hypertrophy using late gadolinium enhancement, T1 mapping and strain-encoded cardiovascular magnetic resonance [Journal Club]-Webinar

Video Transcription

Video Summary

This JCMR Journal Club focused on a study evaluating left ventricular hypertrophy using a multiparametric CMR approach, especially FAST-SENC myocardial strain, T1 mapping, and late gadolinium enhancement (LGE). The investigators compared athletes, healthy controls, hypertensive heart disease, hypertrophic cardiomyopathy (HCM), and amyloidosis patients. They found that FAST-SENC-derived “normal myocardium” and LGE patterns helped distinguish disease groups, particularly in mild-to-moderate hypertrophy where diagnosis is often challenging. Normal myocardium was especially useful for separating athletes from HCM and hypertensive heart disease, while LGE patterns and scores were most helpful for differentiating amyloidosis from HCM. Combining strain with LGE gave the best diagnostic accuracy.<br /><br />The discussion emphasized FAST-SENC’s high reproducibility, fast acquisition, and potential clinical value, while acknowledging trade-offs such as spatial resolution, vendor reproducibility, and the need for broader validation. Limitations included single-center design, no genetic confirmation for all cases, age differences across groups, and some overlapping hypertension. The speakers highlighted the growing importance of early, accurate diagnosis because therapies now exist for conditions like HCM and amyloidosis.

Keywords

left ventricular hypertrophy

FAST-SENC

myocardial strain

T1 mapping

late gadolinium enhancement

hypertrophic cardiomyopathy

amyloidosis

athletes

cardiac magnetic resonance