2022/04 - Bright-blood and dark-blood phase sensitive inversion recovery late gadolinium enhancement and T1 and T2 maps in a single free-breathing scan: an all-in-one approach [Journal Club]-Bright-blood and dark-blood PDF

Video Transcription

Video Summary

The JCMR Virtual Recording Studio opened season 3, episode 4 of the Journal Club with introductions, CME reminders, and recognition of 2021 Gold Star reviewers. Scott Flamm then introduced Dr. Peter Kellman, who presented a novel cardiovascular MRI approach combining T1 and T2 mapping with synthetic late gadolinium enhancement (LGE) in a single free-breathing scan.<br /><br />Dr. Kellman explained that mSASHA measures T1 and T2 simultaneously using saturation-recovery and T2-prepared images, then generates bright-blood and dark-blood PSIR LGE from the resulting maps. This approach aims to provide both diffuse disease assessment and focal scar visualization in one integrated exam. He showed validation data demonstrating accuracy against reference standards and presented patient examples including chronic and acute myocardial infarction, microvascular obstruction, and myocarditis.<br /><br />The discussion covered multicenter deployment, motion correction, arrhythmias, bundle branch block, post-contrast T2 mapping, and applications in infiltrative diseases such as amyloidosis and iron overload. Dr. Kellman noted important limitations, including through-plane motion and reduced dark-blood performance when T2 is markedly elevated, but emphasized that the method is robust and clinically promising. The session concluded with thanks and announcements for upcoming Journal Club events.

Keywords

cardiovascular MRI

T1 mapping

T2 mapping

synthetic LGE

mSASHA

myocardial infarction

myocarditis

motion correction

amyloidosis