2022/08 - Free-running cardiac and respiratory motion-resolved 5D whole-heart coronary cardiovascular magnetic resonance angiography in pediatric cardiac patients using ferumoxytol [Journal Club]-Journal Club Webinar

Video Transcription

Video Summary

The JCMR Journal Club opened with an introduction to its monthly format, CME access, and acknowledgments of key editorial and social media contributors. The featured paper, presented by Oxford investigators, focused on hypertrophic cardiomyopathy (HCM) and the often-overlooked right ventricle (RV). Using cardiac MRI, the study assessed RV size, function, and strain in over 200 HCM patients compared with healthy controls, and also followed a subgroup over about 5 years.<br /><br />At baseline, HCM patients showed reduced RV stroke volume and abnormal RV strain despite largely preserved RV ejection fraction. Over time, RV function and RV strain declined further, while left ventricular function stayed relatively stable. Importantly, reduced RV ejection fraction was associated with nonsustained ventricular tachycardia and composite cardiovascular events, and RV longitudinal strain also predicted nonsustained VT.<br /><br />During discussion, the panel explored technical challenges of RV strain measurement, the meaning of “soft” endpoints like AF and NSVT, possible mechanisms for RV involvement, and how future studies such as HCMR could validate these findings. The presentation concluded that RV dysfunction may provide additional prognostic information in HCM and could become a useful risk marker with larger multicenter validation.

Keywords

hypertrophic cardiomyopathy

right ventricle

cardiac MRI

RV strain

RV dysfunction

ventricular tachycardia

prognostic markers

longitudinal study

HCM risk stratification