2025/03 - Prognostic value of global longitudinal strain in patients with preserved left ventricular systolic function: A cardiac magnetic resonance real-world study [Journal Club]-Prognostic value of global longitudinal strain in patients with preserved left ventricular systolic

Prognostic value of global longitudinal strain in patients with preserved left ventricular systolic

Video Transcription

Video Summary

The JCMR Journal Club episode featured a presentation from Mahidol University on the prognostic value of global longitudinal strain (GLS) measured by cardiac MRI feature tracking in patients with preserved left ventricular systolic function (LVEF >50%). The speakers described a large real-world retrospective cohort of routine CMR patients referred for ischemia/viability assessment. They found that abnormal GLS independently predicted worse outcomes, including death, nonfatal MI, and heart failure, even after adjusting for clinical factors, LVEF, LGE, ischemia, and ECV. The combination of abnormal GLS and LGE identified the highest-risk patients, while normal GLS and no LGE predicted the best prognosis. Sensitivity analyses using different GLS cutoffs gave similar results.<br /><br />The discussion also covered practical issues such as image quality, scan duration, and the advantages of feature tracking over other strain methods. The presenters also highlighted related work showing prognostic value of left atrial strain and the unexpected association of supranormal LVEF with poorer outcomes. The session concluded with questions about cutoff selection, cardio-oncology applications, and workflow in routine CMR practice.

Keywords

global longitudinal strain

cardiac MRI feature tracking

preserved LVEF

prognostic value

left ventricular systolic function

late gadolinium enhancement

myocardial ischemia

heart failure outcomes

Mahidol University