Multi-Center Collaborative Research Subcommittee 2022 Meeting-MCCR Subcommittee Meeting 2022

Video Transcription

Video Summary

The meeting of the Research Collaboration Subcommittee highlighted a wide range of active and newly proposed multicenter pediatric and congenital CMR studies, plus broader infrastructure efforts to speed collaboration.

New study proposals included:  
- <strong>IMPACT</strong>: a randomized, center-assigned study testing whether <strong>3D-printed cardiac models</strong> improve pre-op planning for <strong>VAD placement</strong> in children with systemic RVs or single ventricles, with bypass time as the primary outcome.  
- <strong>Cardiac Index in Repaired Tetralogy of Fallot</strong>: a multicenter retrospective/prospective proposal assessing whether <strong>cardiac index from CMR flow measures</strong> better predicts outcomes and timing of pulmonary valve replacement than current guideline markers.

Ongoing studies reported strong momentum:  
- <strong>Normal ECV/T1 pediatric values</strong>: over 100 subjects collected, 10 fully activated sites, and vendor/software comparisons underway.  
- <strong>FORCE</strong>: the Fontan registry now includes about <strong>2,000 patients</strong> and nearly <strong>3,000 CMRs</strong>, with expansion toward 5,000 patients and many more centers.  
- <strong>MASSIVE</strong>: follow-up of <strong>COVID vaccine-associated myocarditis</strong> cases is underway, focusing on the significance of LGE and comparison with COVID myocarditis/MIS-C.  
- <strong>CLARITY</strong>: a funded aortopathy registry has 40 sites and aims to model aortic growth, dissection, and death.  
- <strong>Borderline LV</strong>: a new multicenter project is being finalized to study CMR predictors of biventricular vs single-ventricle pathways.  
- <strong>Transplant rejection</strong>: an R01 proposal is under review to integrate CMR, blood biomarkers, histology, and microRNA.  
- <strong>CeraMIC/CARDOVID and other COVID-related studies</strong> also gave updates.

Additional initiatives included <strong>PRISM</strong>, a mentorship network for junior and mid-career imaging investigators; the <strong>GAP committee</strong>, which ranked key research gaps; and a proposed <strong>open consortium/registry infrastructure</strong> to simplify DUAs, IRBs, shared databases, and image repositories for future studies.

Keywords

multicenter pediatric CMR

congenital heart disease

3D-printed cardiac models

VAD placement

cardiac index

Tetralogy of Fallot

Fontan registry

myocarditis

aortopathy registry

research collaboration infrastructure