Oral Abstract Session 01: Early Career Awards 1: Clinical (2018)-Native myocardial T1 for clinical diagnosis of cardiac amyloidosis: ready for prime time

Native myocardial T1 for clinical diagnosis of cardiac amyloidosis: ready for prime time – a 715 patient prospective study

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Video Summary

The speaker presented a large prospective study of 868 patients with suspected systemic amyloidosis to test whether native myocardial T1 on non-contrast CMR can diagnose cardiac amyloidosis without gadolinium. Native T1 showed excellent accuracy in both AL and ATTR amyloidosis, including patients with renal dysfunction and even those without LV hypertrophy. Two thresholds were proposed: below 1,036 ms to exclude cardiac amyloidosis and above 1,164 ms to confirm it. Native T1 was minimally affected by kidney function, supporting a practical non-contrast diagnostic algorithm that may reduce contrast exposure and shorten scan time.

Keywords

native myocardial T1

cardiac amyloidosis

CMR

gadolinium-free diagnosis

systemic amyloidosis