Oral Abstract Session 02: Early Career Awards 2: Translational (2018)-Fractal analysis of right ventricular trabeculae in pulmonary hypertension

Fractal analysis of right ventricular trabeculae in pulmonary hypertension

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Tim Dawes presented a study on fractal analysis of right ventricular trabeculae in pulmonary hypertension. Using a new automated CMR-based pipeline, his team quantified right ventricular trabecular complexity and found it was highly reproducible. In 256 pulmonary hypertension patients, higher apical right ventricular fractal dimension correlated with worse hemodynamics, greater pulmonary vascular resistance, and markers of adverse remodeling. Most importantly, trabecular complexity predicted survival, with large differences in estimated lifespan between low- and high-risk groups. The study suggests right ventricular trabecular structure is an important functional adaptation and a novel prognostic marker in pulmonary hypertension.

Keywords

pulmonary hypertension

right ventricular trabeculae

fractal analysis

cardiac MRI

prognostic marker