Oral Abstract Session 02: Early Career Awards 2: Translational (2018)-Microvascular Dysfunction is a Coronary Artery Specific Phenomenon, associated with Elevated Microvascular Resistance, Myocardial Hypo-Perfusion and Dysfunction

Microvascular Dysfunction is a Coronary Artery Specific Phenomenon, associated with Elevated Microvascular Resistance, Myocardial Hypo-Perfusion and Dysfunction - Time for a Paradigm Shift

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Video Summary

The talk describes patients with angina and unobstructed coronary arteries, where microvascular dysfunction is often missed and difficult to diagnose. Researchers tested stress perfusion CMR against invasive index of microcirculatory resistance (IMR) in 60 patients and controls. CMR markers, especially MPRI and absolute myocardial blood flow, accurately identified microvascular ischemia, including subtle disease and regional single- or multivessel involvement. Reduced stress flow also correlated with impaired systolic and diastolic function. The speaker concludes that CMR can objectively diagnose both epicardial and microvascular coronary disease in one scan, improving diagnosis, monitoring, and future treatment.

Keywords

microvascular dysfunction

stress perfusion CMR

index of microcirculatory resistance

myocardial blood flow

coronary artery disease