Oral Abstract Session 04: Early Career Awards 3: Basic Science (2018)-Staging reperfused myocardial infarctions with T2 CMR: insights into the dependence on infarction type with ex-vivo validation

Staging reperfused myocardial infarctions with T2 CMR: insights into the dependence on infarction type with ex-vivo validation

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Video Summary

The speaker presents research on myocardial infarction staging, questioning whether T2 imaging alone can distinguish acute from chronic infarction. In an animal model, hemorrhagic and non-hemorrhagic infarcts were imaged acutely and at 8 weeks using T2, T2*, and late gadolinium enhancement at 1.5T and 3T. Results showed persistent iron deposition and prolonged inflammation in hemorrhagic infarcts, causing lingering edema and confounding T2-based staging. Histology confirmed iron and macrophage infiltration. Conclusion: T2 elevation does not always mean acute MI, and T2/T2* assessment of iron improves staging accuracy.

Keywords

myocardial infarction staging

T2 imaging

hemorrhagic infarction

iron deposition

late gadolinium enhancement