Oral Abstract Session 04: Early Career Awards 3: Basic Science (2018)-The dependence of fatty remodeling of infarct territories on iron remnants from acute myocardial infarctions: a serial CMR study

The dependence of fatty remodeling of infarct territories on iron remnants from acute myocardial infarctions: a serial CMR study

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The study examined whether iron from acute hemorrhagic myocardial infarction predicts later fat remodeling. In 12 dogs, serial 3T CMR with multigradient echo was used to measure iron (R2*) and fat fraction over six months. Hemorrhagic infarcts showed persistently elevated iron compared with non-hemorrhagic ones, while fat fraction nearly doubled over time. Correlation between iron and fat became very strong in late chronic MI (R² = 0.89). Histology confirmed co-localization. The findings suggest iron deposition after hemorrhagic MI drives chronic fat infiltration, which may contribute to worse clinical outcomes.

Keywords

hemorrhagic myocardial infarction

iron deposition

fat remodeling

cardiac MRI

chronic infarction