SCMR/ISMRM Workshop: Advanced Image Acquisition Strategies for Quantitative Cardiac MRI-Myocardial Tissue Oxygenation and Microvascular Blood Volume Measurement Using a Contrast-BOLD Model

Myocardial Tissue Oxygenation and Microvascular Blood Volume Measurement Using a Contrast-BOLD Model

Video Transcription

Video Summary

The speaker explains BOLD MRI of the myocardium, tracing its origins in brain imaging and the role of deoxyhemoglobin in T2*-weighted signal changes. He presents a contrast-reference model using the intravascular agent MION to separate microvascular blood volume from tissue oxygenation effects. In rat studies with adenosine or dobutamine, four R2* maps were acquired to compare baseline, drug-only, contrast-only, and combined conditions. Results suggest adenosine increases myocardial oxygenation with little volume change, while dobutamine increases microvascular blood volume but preserves oxygenation. The approach may help translate cardiac oxygenation imaging to humans.

Keywords

BOLD MRI

myocardial oxygenation

deoxyhemoglobin

microvascular blood volume

R2* mapping