Scientific Abstracts - Pediatric and Congenital Heart Disease Scientific Presentations-Myocardial T1 at 3T is Repeatable and Detects Progressive Changes in Duchenne Muscular Dystrophy

Myocardial T1 at 3T is Repeatable and Detects Progressive Changes in Duchenne Muscular Dystrophy

Video Transcription

Video Summary

The speaker presented a study on cardiac MRI biomarkers in Duchenne muscular dystrophy (DMD), a fatal genetic disease in boys. The team tested whether myocardial T1 mapping at 3T is repeatable and sensitive to disease progression. In 25 boys with DMD and 20 controls, pre- and post-contrast T1 and extracellular volume (ECV) showed good intra-exam repeatability. In 9 boys followed over time, ECV was the only biomarker to detect progressive myocardial change, suggesting diffuse fibrosis may progress before obvious T1 changes. T1 mapping appears useful for monitoring early cardiac involvement in DMD.

Keywords

Duchenne muscular dystrophy

cardiac MRI biomarkers

T1 mapping

extracellular volume

myocardial fibrosis