Short Lecture 03: Clinical Trials and Drug Development by CMR (2018)-How imaging can become a key player in the future of clinical trial and drug development

How imaging can become a key player in the future of clinical trial and drug development

Video Transcription

Video Summary

The speaker describes experience running cardiac MRI core labs for trials of drugs and other therapies. Core labs help sponsors find early signals, reduce costs, and improve efficiency before large outcome trials. Quantitative MRI is emphasized as more reliable than qualitative assessment because small improvements in reproducibility greatly reduce sample size and cost. The speaker discusses trials in myocardial infarction and omega-3 therapy, where MRI detected modest structural benefits and helped identify subgroups that responded differently through biomarkers and genetics. Overall, cardiac MRI is presented as a powerful, noninvasive tool for studying disease mechanisms and guiding therapy development.

Keywords

cardiac MRI

core labs

clinical trials

quantitative imaging

myocardial infarction