Technical - Interventional CMR-Native T1w MRI Visualizes Patterns of RF Lesions in MRI-Defined Arrhythmia Substrate Targeted Using a State of the Art EP System in a Pre-Clinical Chronic Infarct Model

Native T1w MRI Visualizes Patterns of RF Lesions in MRI-Defined Arrhythmia Substrate Targeted Using a State of the Art EP System in a Pre-Clinical Chronic Infarct Model

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This study showed that native T1-weighted MRI can reliably visualize radiofrequency ablation lesions placed in MR-defined arrhythmia substrate in a preclinical swine infarct model. Researchers targeted heterogeneous tissue channels, scar border zones, and dense scar using a commercial electrophysiology system, then compared MRI with electrophysiology maps, pathology, and histology. Lesion patterns matched well across methods, with strong agreement in location and size. MRI also reflected whether lesions eliminated inducible ventricular tachycardia in some animals. The work suggests native T1 MRI could help verify ablation completeness and improve ventricular arrhythmia treatment.

Keywords

native T1 MRI

radiofrequency ablation

ventricular arrhythmia

scar border zone

preclinical swine model