Techniques and Methods Session 4: Rethinking Imaging of Function, Flow, Perfusion, and Morphology (2020)-Variability in myocardial perfusion quantification due to the arterial input sampling location

Variability in myocardial perfusion quantification due to the arterial input sampling location

Video Transcription

Video Summary

The study tested how arterial input function (AIF) sampling location affects myocardial blood flow (MVF) quantification by CMR perfusion. In 25 patients, AIFs were sampled at seven sites from the RV to the ascending aorta, with scans repeated for reproducibility. Results showed AIF shape changed by location and significantly altered MVF estimates, with LV-based sampling yielding higher MVF than other sites, likely from partial-volume effects. MVF was reproducible at each site, best in the ascending aorta. The authors conclude alternative AIF locations are feasible, but location-specific thresholds are needed.

Keywords

arterial input function

myocardial blood flow

CMR perfusion

partial-volume effects

ascending aorta